曹碧茵

发布者:金雪明发布时间:2019-03-27浏览次数:3902



姓    名:曹碧茵
职称职务:副研究员
电子邮箱:caobiyin@suda.edu.cn
办公地址:云轩楼1227 


一、学习工作经历
1
、学历背景:
1996.9-2001.7  河南中医学院,本科
2002.9-2007.6  上海中医药大学,博士(硕博连读)

2
、工作经历:
2007.10-2009.10  我校附属第二医院,博士后
2009.12-2014.06  我校唐仲英血液学研究中心,助理研究员
2014.06-2015.06  加拿大多伦多大学儿童医院,访问学者

2014.06-2017.12   我校医学部拉斯维加斯登录网站3133药理系,助理研究员

2018.01       至今  我校医学部拉斯维加斯登录网站3133药理系,副研究员


二、研究方向
1)肿瘤药理学
2)中药药理学 


三、主要研究成果
主持国家自然科学基金、江苏省自然科学基金、苏州市科技民生等科研项目,并参与国家自然科学基金面上项目及重点项目。近年来发表SCI论文十余篇。
1
、论文

  1. Jiefei Tong#, Biyin Cao #, Gregory D. Martyn, Jonathan R. Krieger, Paul Taylor, Bradley Yates, Sachdev S. Sidhu, Shawn S. C. Li, Xinliang Mao, Michael F. Moran*, Protein-phosphotyrosine proteome profiling by superbinder-SH2 domain affinity purification mass spectrometry, sSH2-AP-MS, Proteomics, 2017, 17(6):1600360. (#Co-first author)

  2. Biyin Cao, Jie Li, Jingyu Zhu, Mingyun Shen, Kunkun Han, Zubin Zhang, Yang Yu, Yali Wang, Depei Wu, Suning Chen, Aining Sun, Xiaowen Tang, Yun Zhao, Chunhua Qiao, Tingjun Hou, Xinliang Mao*, The antiparasitic clioquinol induces apoptosis in leukemia and myeloma cells by inhibiting histone deacetylase activity, J Biol Chem, 2013, 288(47):34181-9

  3. Biyin Cao, Jie Li, Xiumin Zhou, Jiaxiang Juan, Kunkun Han, Zubin Zhang, Yan Kong, Jianrong Wang, Xinliang Mao*, Clioquinol induces pro-death autophagy in leukemia and myeloma cells by disrupting the mTOR signaling pathway, Sci Rep, 2014, 4:5749

  4. Jie Li#, Biyin Cao#, Shunye Zhou, Jingyu Zhu, Zubin Zhang, Tingjun Hou, Xinliang Mao*, Cyproheptadine- induced myeloma cell apoptosis is associated with inhibition of the PI3K/AKT signaling, Eur J Haematol, 2013, 91(6):514-21. (#Co-first author)

  5. Biyin Cao, Jie Li, Xinliang Mao*, Dissecting bortezomib: development, application, adverse effects and future direction, Curr Pharm Des, 2013, 19(18):3190-200

  6. Biyin Cao, Xinliang Mao*, The ubiquitin-proteasomal system is critical for multiple myeloma: implications in drug discovery, Am J Blood Res, 2011,1(1):46-56.

  7. Bi-Yin Cao, Ya-Ping Yang, Wei-Feng Luo, Cheng-Jie Mao, Rong Han, Xue Sun, Jing Cheng, Chun-Feng Liu*, Paeoniflorin, a potent natural compound, protects PC12 cells from MPP+ and acidic damage via autophagic pathway, J Ethnopharmacol, 2010, 131(1):122-9

  8. Siyu Wang, Jie Li, Yanyun Du, Yujia Xu, Yan Wang, Zubin Zhang, Zhuan Xu, Yuanying Zeng, Xinliang Mao*, Biyin Cao*. The Class I PI3K inhibitor S14161 induces autophagy in malignant blood cells by modulating the Beclin1/Vps34 complex. J Pharmacol Sci. 2017; 134(4):197-202.

  9. Xin Xu, Jieyu Zhang, Kunkun Han, Zubin Zhang, Guodong Chen, Jinping Zhang, Xinliang Mao*, Biyin Cao*, Natural pesticide dihydrorotenone arrests human plasma cancer cells at the G0/G1 phase of the cell cycle, J Biochem Mol Toxicol, 2014, 28(5): 232-8


2、课题

  1. 国家自然科学基金面上项目,81770215,泛素结合酶UBE2O介导c-Maf蛋白泛素化的分子机制及其在多发性骨髓瘤中的意义,2018/01-2021/1255万元,在研,主持。

  2. 国家自然科学基金青年项目,81101795,新型PI3K抑制剂诱导多发性骨髓瘤细胞死亡的分子机理研究,2012/01-2014/1223万元,已结题,主持。

  3. 江苏省自然科学基金项目,BK2011268,氯碘羟喹抑制HDACs诱导多发性骨髓瘤细胞凋亡的分子机理研究,2011/07-2014/068万元,已结题,主持。

  4. 国家自然科学基金面上项目,30870869α-synuclein降解中的自噬调控机制,2009/01- 2011/1235万元,已结题,参与。


四、主要荣誉
2010
年  苏州市科技进步一等奖(排名第五)
2018
年  我校优秀班主任


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