贾佳

姓　　名：贾佳

职称职务：教授

联系电话：0512-65881160

电子邮箱：jiajia@suda.edu.cn

办公地址：云轩楼1337

个人简介：

一、学习工作经历
2000.9-2004.6  暨南大学本科
2004.9-2009.10 南京大学生化与分子生物学博士生, Ph.D
2007.10-2009.8 南京大学和美国俄勒冈医科大学联合培养博士生

2009.11-2011.4 美国俄勒冈医科大学博士后

2011.5- 2020.7我校拉斯维加斯登录网站3133副教授

2020.7- 现在 我校拉斯维加斯登录网站3133教授

二、研究方向
脑血管病损伤及修复机制研究

三、主要研究成果

1、主要代表性论文

1.         Wang X#,Chen S#, Ni J, Cheng J, Jia J*, Zhen X*. miRNA-3473b contributes to neuroinflammation following cerebral ischemia. Cell Death Dis. 2018 Jan 9;9(1):11.

2.          Zhang M#, Wu X#, Xu Y, He M, Yang J, Li J, Li Y, Ao G, Cheng J*, Jia J*. The cystathionine β-synthase/hydrogen sulfide pathway contributes to microglia-mediated neuroinflammation following cerebral ischemia. Brain Behav Immun. 2017 Nov;66:332-346. 

3.        Liu H, Wang Y, Xiao Y, Hua Z, Cheng J*, Jia J*.Hydrogen Sulfide Attenuates Tissue Plasminogen Activator-Induced Cerebral Hemorrhage Following Experimental Stroke. Transl Stroke Res. 2016 Jun;7(3):209-19.

4.         Chen Y, Zhang L, Ni J, Wang X, Cheng J, Li Y, Zhen X, Cao T*, Jia J*. LLDT-8 protects against cerebral ischemia/reperfusion injury by suppressing post-stroke inflammation.J Pharmacol Sci. 2016 Jun;131(2):131-7.

5.         Jia J, Davis CM, Zhang W, Edin ML, Jouihan S, Jia T, Bradbury JA, Graves JP, DeGraff LM, Lee CR, Ronnekleiv O, Wang R, Xu Y, Zeldin DC, Alkayed NJ*. Sex- and isoform-specific mechanism of neuroprotection by transgenic expression of P450 epoxygenase in vascular endothelium. Exp Neurol. 2016 Feb 20;279:75-85.

6.        Ni J, Wang X, Xu X , Liu H, Wang Y, Cheng J, Jia J*, Zhen X*. MicroRNA let-7c-5p protects against cerebral ischemia injury via mechanisms involving the inhibition of microglia activation. Brain, Behavior, and Immunity. 2015; 49:75-85.

7.        Liu Y, Wang W, Li Y, Xiao Y, Cheng J, Jia J. The 5-Lipoxygenase Inhibitor Zileuton Confers Neuroprotection against Glutamate Oxidative Damage by Inhibiting Ferroptosis. Biol Pharm Bull. 2015; 38(8):1234-9.

8.         Jia J*, Cheng J, Ni J, Zhen X*. Neuropharmacological Actions of Metformin in Stroke. Curr Neuropharmacol. 2015;13(3):389-94.

9.         Jin Q, Cheng J, Liu Y, Wu J, Wang X, Wei S, Zhou X, Qin Z, Jia J*, Zhen X*.Improvement of functional recovery by chronic metformin treatment is associated with enhanced alternative activation of microglia/macrophages and increased angiogenesis and neurogenesis following experimental stroke. Brain Behav Immun. 2014 Aug;40:131-42.

10.     Zhou X, Cao Y, Ao G, Hu L, Liu H, Wu J, Wang X, Jin M, Zheng S, Zhen X, Alkayed NJ, Jia J*, Cheng J*. CaMKKβ-Dependent Activation of AMP-Activated Protein Kinase Is Critical to Suppressive Effects of Hydrogen Sulfide on Neuroinflammation. Antioxid Redox Signal. 2014 Oct 20;21(12):1741-58.

11.     Jia J, Xiao Y, Wang W, Qing L, Xu Y, Song H, Zhen X, Ao G, Alkayed NJ, Cheng J. Differential mechanisms underlying neuroprotection of hydrogen sulfide donors against oxidative stress. NEUROCHEM INT 2013 Jun;62(8):1072-8.

12.     Jia J, Verma S, Nakayama S, Grafe MR, MD, Hurn PD and Herson PS. Sex differences in neuroprotection provided by inhibition of TRPM2 channels following experimental stroke. JCBFM 2011 May 18.

13.     Jia J, Guan D, Zhu W, Alkayed NJ, Wang MM, Hua Z, Xu Y. Estrogen Inhibits Fas-Mediated Apoptosis in Experimental Stroke. Experimental Neurology 2009 Jan; 215(1):48-52.

14.     Iliff J, Jia J, Nelson J,  Goyagi N, Klaus J, Alkayed NJ. Epoxyeicosanoid signaling in CNS function and disease. POLM 2009 Jun 21. (共第一作者)

15.     Jia J, Chen X, Zhu W, Luo Y, Hua Z, Xu Y. CART protects brain from damage through ERK activation in ischemic stroke. Neuropeptides 2008 Oct-Dec; 42(5-6):653-61.

2、主持课题
国家自然科学青年基金（81100918）：巨噬细胞选择性活化对缺血性卒中后神经再生的影响

国家自然科学基金面上项目（81371278）：硫化氢诱导小胶质细胞M2极化促进脑缺血后血管新生的机制研究

国家自然科学基金面上项目（81571124）：硫化氢氧化代谢促进脑出血后血肿清除的新机制