阮建清

阮建清

我校，拉斯维加斯登录网站3133，副教授

江苏省高层次创新创业人才

学历：香港中文大学博士

电子邮箱：ruanjianqing@suda.edu.cn

办公地址：云轩楼1130

研究方向：

1.肝细胞内药物代谢转运研究

2.药物的一期临床研究

3.药物吸收、分布、代谢、排泄以及体内DMPK机制研究

科研与学术工作经历：

1.2014/9-至今，我校，拉斯维加斯登录网站3133，副教授

2.2013/9-2014/8，香港中文大学，博士后

主持科研项目（课题）：

1. 国家自然科学基金青年科学基金项目，81703596，不同糖基侧链的黄酮苷对OATP转运功能调节的机制研究，2018/01-2020/12，20.2万元，在研，主持

2. 江苏省自然科学基金-青年基金，BK20150349，大黄有机酸成分代谢活化与药物转运体的相互作用研究， 2015/07-2018/06，20万元，结题，主持

代表性研究成果

1. 第一作者与通讯作者论文

(1) Yang Mengbi^(#), Ruan Jianqing^(#), Gao Hong, Li Na, Ma Jiang, Xue Junyi, Ye Yang, Fu Peter Pi-Cheng, Wang Jiyao, Lin Ge^(*).First evidence of pyrrolizidine alkaloid N‑oxide‑induced hepatic sinusoidal obstruction syndrome in humans. Arch Toxicol, 2017.12, 91（12）：3913~3925（共一）（影响因子5.779）

(2) Ruan, Jian-Qing，Li, Shang，Li, Ya-Ping，Wu, Wen-Jin，Lee, Simon Ming-Yuen，Yan, Ru^(*)，The Presystemic Interplay between Gut Microbiota and Orally Administered Calycosin-7-O-beta-D-Glucoside.，Drug Metab Dispos，2015.10.01，43（10）：1601~1611 （影响因子3.615）

(3) Ruan, Jianqing^(#)，Gao, Hong^(#)，Li, Na，Xue, Junyi，Chen, Jie，Ke, Changqiang，Ye, Yang，Fu, Peter Pi-Cheng，Zheng, Jiang，Wang, Jiyao，Lin,Ge^(*)，Blood Pyrrole-Protein Adducts-A Biomarker of Pyrrolizidine Alkaloid-Induced Liver Injury in Humans.，J Environ Sci Health C Environ Carcinog Ecotoxicol Rev，2015.10.2，33（4）：404~421 （影响因子4.235）

(4) Ruan, Jianqing，Yang, Mengbi，Fu, Peter，Ye, Yang，Lin, Ge^(*)，Metabolic activation of pyrrolizidine alkaloids: insights into the structural and enzymatic basis.，Chemical Research in Toxicology，2014.6.16，27（6）：1030~1039 （影响因子3.867）

(5) Ruan, Jianqing，Liao, Cangsong，Ye, Yang，Lin, Ge^(*)，Lack of metabolic activation and predominant formation of an excreted metabolite of nontoxic platynecine-type pyrrolizidine alkaloids.，Chemical Research in Toxicology，2014.1.21，27（1）：7~16（影响因子3.867）

(6) Ruan, Jian-Qing，Yan, Ru^(*)，Regioselective glucuronidation of the isoflavone calycosin by human liver microsomes and recombinant human UDP-glucuronosyltransferases.，Chem Biol Interact，2014.9.5，220：231~240（影响因子3.308）

(7) Ruan, Jianqing，Li, Na，Xia, Qingsu，Fu, Peter P，Peng, Shuying，Ye,Yang，Lin, Ge^(*)，Characteristic ion clusters as determinants for the identification of pyrrolizidine alkaloid N-oxides in pyrrolizidine alkaloid-containing natural products using HPLC-MS analysis.，Journal of Mass Spectrometry，2012.3.01，47（3）：331~337 (影响因子2.188)

(8) Ruan, Jian-Qing，Leong, Weng-Im，Yan, Ru^(*)，Wang, Yi-Tao，Characterization of metabolism and in vitro permeability study of notoginsenoside R1 from Radix notoginseng.，Journal of Agricultural and Food Chemistry，2010.5.12，58（9）：5770~5776 （影响因子3.791）

(9) Yuan, Yuan, Yang, Hua, Kong, Linghua, Li, Yuan, Li, Ping, Zhang, Hongjian, Ruan, Jianqing^(*).Interaction between rhein acyl glucuronide and methotrexate based on human organic anion transporters. Chem Biol Interact. 2017. 11.1，277：79~84 通讯作者（影响因子3.308）

(10) Yuan, Yuan，Zheng, Jiyue，Wang, Meiyu，Li, Yuan，Ruan, Jianqing^(*)，Zhang, Hongjian^(*)，Metabolic Activation of Rhein: Insights into the Potential Toxicity Induced by Rhein-Containing Herbs.，J Agric Food Chem，2016.7.20，64（28）：5742~5750通讯作者（影响因子3.791）

2. 其它论文

(11) Mengbi Yang, Jianqing Ruan, Peter P.Fu, Ge Lin. Cytotoxicity of pyrrolizidine alkaloid in human hepatic parenchymal and sinusoidal endothelial cells: Firm evidence for the reactive metabolites mediated pyrrolizidine alkaloid-induced hepatotoxicity. Chem Biol Interact. 2016;243:119-26.

(12) Nan Hu, Mei Mei, Jianqing Ruan, Wenjin Wu, Yitao Wang, Ru Yan. Regioselective Glucuronidation of Oxyresveratrol, a Natural Hydroxystilbene, by Human Liver and Intestinal Microsomes and Recombinant UGTs. Drug Metab Pharmacokinet. 2014;29(3):229-36.

(13) Na Li, Qingsu Xia, Jianqing Ruan, Peter P. Fu, Ge Lin. Hepatotoxicity and Tumorigenicity Induced by Metabolic Activation of Pyrrolizidine Alkaloids in Herbs. Curr Drug Metab. 2011;12(9):823-34.

(14) Zhu Lin, Ruan Jianqing, Li Na, Fu PP, Ye Yang, Lin Ge. A novel ultra-performance liquid chromatography hyphenated with quadrupole time of flight mass spectrometry method for rapid estimation of total toxic retronecine-type of pyrrolizidine alkaloids in herbs without requiring corresponding standards. Food Chem. 2016;194:1320-8.

(15) Yan-Hong Li, William Chi-Shing Tai, Jun-Yi Xue, Wing-Yan Wong, Cheng Lu, Jian-Qing Ruan, Na Li, Tai-Fung Wan, Wood-Yee Chan, Wen-Luan Wendy Hsiao, and Ge Lin. Chem Res Toxicol. 2015;28(9):1715-27.

(16) Hong Shen, Weng-Im Leung, Jian-Qing Ruan, Song-Lin Li, Jacky Pui-Cheong Lei, Yi-Tao Wang, and Ru Yan. Biotransformation of ginsenoside Rb1 via the gypenoside pathway by human gut bacteria. Chin Med. 2013;8(1):22.

(17) Rui-Na Zhou, Yue-Lin Song, Jian-Qing Ruan, Yi-Tao Wang, Ru Yan. Pharmacokinetic Evidence on the Contribution of Intestinal Bacterial Conversion to Beneficial Effects of Astragaloside IV, a Marker Compound of Astragali Radix, in Traditional Oral Use of the Herb. Drug Metab Pharmacokinet. 2012;27(6):586-97.

(18) Mei Mei, Jian-Qing Ruan, Wen-Jin Wu, Rui-Na Zhou, Jacky Pui-Cheong Lei, Hai-Yu Zhao, Ru Yan, and Yi-Tao Wang. In Vitro Pharmacokinetic Characterization of Mulberroside A, the Main Polyhydroxylated Stilbene in Mulberry (Morus alba L.), and Its Bacterial Metabolite Oxyresveratrol in Traditional Oral Use. J Agric Food Chem. 2012;60(9):2299-308.