季兴跃 拉斯维加斯登录网站3133云轩楼1237(Office);1510,1517(Lab) Email: jixy@suda.edu.cn; Home page: www.researchgate.net/profile/Xingyue-Ji |
课题组长期招聘具有药理学、药物化学、化学生物学等学科背景的研究人员,可提供副教授、讲师、博士后,助理研究员等职位。
11/2018-至今:我校,拉斯维加斯登录网站3133,特聘教授
12/2014-10/2018:Research Scientist, 佐治亚州立大学化学系
12/2013-12/2014: 博士后,佐治亚州立大学化学系
09/2011-12/2013: 助理研究员,北京协和医学院医药生物技术研究所
北京科技大学应用学院,应用化学/分析化学
博士 (9/2008 – 7/2011)
北京协和医学院医药生物技术研究所, 微生物与生化药学
² 气体信使小分子(CO, H2S等)药物化学生物学研究:发展新颖的脱笼(decaging)化学,用于气体信使小分子的可控靶向递送,并研究其在相关重大疾病的发生、发展以及治疗方面的作用。
² 新型Click化学的发现及其相关化学生物学研究:发展新颖的Click反应,并用于相关的化学生物学研究,包括生物正交前药的设计,生物大分子的可逆可视化标记等。
² 抗感染、抗肿瘤靶向小分子药物的设计合成:基于传统药物化学策略,进行抗感染、抗肿瘤小分子靶向药物的设计与合成。
1. 2022-2024,江苏省特聘教授特别资助,200万,项目负责人.
2. 2023-2026,国家自然科学基金面上项目,54万,项目负责人.
3. 2019-2022,江苏省六大人才高峰,4万,项目负责人.
4. 2017-2020,中国医学科学院医学与健康科技创新工程,160万元,项目负责人.
5. 2018-2021, 国家自然科学基金面上项目(81773608),58.5 万元,项目负责人.
6. 2015-2017,国家自然科学基金青年项目 (81402827), 23万元,项目负责人.
2. Xingyue Ji,# Zhixiang Pan,# Chunjie Li, Ting Kang, Ladie Kimberly C De La Cruz, Lingyun Yang, Zhengnan Yuan, Bowen Ke, Binghe Wang. Esterase-Sensitive and pH-Controlled Carbon Monoxide Prodrugs for Treating Systemic Inflammation.J. Med. Chem.2019, 62, 3163-3168. (IF: 8.0)
3. Xingyue Ji, Robert E Aghoghovbia, Ladie Kimberly C De La Cruz, Zhixiang Pan, Xiaoxiao Yang, Bingchen Yu, Binghe Wang*. Click and Release: A High-Content Bioorthogonal Prodrug with Multiple Outputs. Org. Lett.2019, 21, 3649-3652. (IF: 6.0)
4. Xingyue Ji*, Zhuo-Rong Li*. Medicinal chemistry strategies toward host targeting antiviral agents. Med. Res. Rev. 2020, 40, 1519-1557. (IF: 12.3)
5. Shengchao Zhou, Yujie Mou, Miao Liu, Qian Du, Basharat Ali, Jurupula Ramprasad, Chunhua Qiao, Li-Fang Hu*, Xingyue Ji*. Insights into the Mechanism of Thiol Triggered COS/H2S Release from N-Dithiasuccinoyl Amines. J. Org. Chem. 2020, 85(13):8352-8359. (IF: 4.3)
6. Eman Moussa Ellabbad,* Xingyue Ji*, Khaled Abouzid, Binghe Wang. Medicinal Chemistry Strategies Towards SO2 Donors as Research Tools and Potential Therapeutics. Curr. Top. Med. Chem. 2021, 21, 2870-2881. (IF: 3.3)
7. Zhou Zhou, Shun Feng, Jujun Zhou, Xingyue Ji*, Ya-Qiu Long*. On-Demand Activation of a Bioorthogonal Prodrug of SN-38 with Fast Reaction Kinetics and High Releasing Efficiency In Vivo. J. Med. Chem. 2022, 65(1):333-342. (IF: 8.0)
8. Qingqiang Min,# Zihui Ni,# Meng You, Miao Liu, Zhou Zhou, Hengte Ke*, Xingyue Ji*. Chemiexcitation-Triggered Prodrug Activation for Targeted Carbon Monoxide Delivery. Angew. Chem. Int. Ed. 2022, 61, e202200974. (IF: 16.3)
9. Xingyue Ji*, Zhiyuan Zhong*. External stimuli-responsive gasotransmitter prodrugs: Chemistry and spatiotemporal release. J. Control. Release. 2022, 351, 81-101. (IF: 11.0)
10. Ru Dong, Xiaoxiao Yang, Binghe Wang,* Xingyue Ji*. Mutual leveraging of proximity effects and click chemistry in chemical biology. Med. Res. Rev.2023, doi:10.1002/med.21927. (IF: 12.3)
11. Qingqiang Min, Xingyue Ji.* Strategies toward Metal-Free Carbon Monoxide Prodrugs: An Update. ChemMedChem, 2023, 18(1): e202200500. (Invited review) (IF: 3.5)
12. Miao Liu, Yuhan Wang, Zhicheng Yan, Jiabin Yang, Yongyou Wu*, Dawei Ding*, Xingyue Ji*. Photoclick and Release: Co-activation of Carbon Monoxide and a Fluorescent Self-reporter, COS or Sulfonamide with Fast Kinetics. ChemBioChem, 2023, DOI: 10.1002/cbic.202200506. (IF: 3.5).
Publications before 2019 can be found at our researchgate home page.