赵宁

姓名：赵宁

职务：兼职教授，苏州吉玛基因股份有限公司，新药研发总监，国家级重大人才工程青年人才

电子邮箱：zhn_2020@hotmail.com

研究方向：核酸药物及其递送技术的研究和开发

一、学习工作经历

1．学历背景

2006.8-2010.7 兰州大学，化学学士

2011.8-2016.12 路易斯安那州立大学，有机化学博士

2．工作经历

2023.5－至今，我校兼职教授

2021.9－至今，新药研发总监，苏州吉玛基因股份有限公司，苏州，中国

2018.4－2021.9 博士后, 加州大学旧金山分校，旧金山，加州，美国

2017.2－2018.3 高级科学家, AnaSpec公司，弗里蒙特，加州，美国

二、研究方向

  赵宁博士擅长有机化学和药物化学，尤其在靶向药物的研究上有着丰富的科研经历。迄今为止已发表20余篇高水平科研论文，多篇论文发表在Clinical Cancer Research, ACS Central Science, J Experimental Medicine等权威杂志上。在美国工作期间，主持开发了大量创新生物药的研发项目，多个产品已经申报或在临床试验阶段。赵宁博士曾获得了多个奖项，包括被SNMMI协会选为“2021年全球30位值得关注的青年科学家”以及2022年国家重大人才工程（青年人才）。赵宁博士目前现任职于苏州吉玛基因股份有限公司，主要负责核酸药物及其递送技术的研究和开发。

三、代表性学术论文

论文：

1.      Zhao, N.;Bardine, C.; Lourenço, A.L.; Wang, Y-H.; Huang, Y.; Cleary, S.J.; Wilson, D.M.; Oh, D.Y.; Fong, L.; Looney, M.R.; Evans, M.J.; Craik, C.S. In vivo measurement of granzyme proteolysis from activated immune cells with PET. ACS Central Science,2021, 7, 1638. （Futured as Front Cover Art）

2.      Zhao, N.;Trepka,K.; Wang, Y.-H.; Chopra, S.; Hooshdaran, N.; Kim, H.; Zhuo, J.; Lim, A. S.; Yang, J.; Leung_, K.K.; Zhang, L.; Foye, A.; Chou, J.; Feng, Y.F.; Small, E.J.; Wells, J.A.; AggarwalR.;Evans,M.J. CUB domain containing protein 1 (CDPC1) is a target for radioligand therapy in castration resistant prostate cancer, Clinical Cancer Research, 2022, 28. 3066-3075.

3.      Zhao, N.; Huang, Y.; Wang, Y.-H.; Muir, R. K.; Chen, Y.-C.; Wei, J.; Viswanath, P.; Seo, Y.; Ruggero, D.; Renslo, A. R.; Evans, M. J. Ferronostics: Measuring Tumoral Ferrous Iron with PET to Predict Sensitivity to Iron-Targeted Cancer Therapies. Journal of Nuclear Medicine, 2021. 62. 949.

4.      Muir, R. K.^†; Zhao, N.^†; Wei, J.; Wang, Y.-H.; Moroz, A.; Huang, Y.; Chen, Y.-C.; Sriram, R.; Kurhanewicz, J.; Ruggero, D.; Renslo, A. R.; Evans, M. J.Measuring Dynamic Changes in the Labile Iron Pool In Vivo with a Reactivity-Based Probe for Positron Emission Tomography. ACS Central Science, 2019, 54, 727. (^†co-first author)

5.      Zhao, N.; Bobadova-Parvanova, P.; Vicente, M.G.H. Design, Synthesis and Properties of Boron-containing Polymers. Invited Chapter for a book entitled” Boron Chemistry in Organometallics, Catalysis, Materials, and Medicine”, World Scientific Publishers, 2018

6.      Zhao, N.; Xuan, S.; Zhou, Z.; Franczek, F. R.; Smith, K. M.; Vicente, M.G.H. Synthesis, Spectroscopic and Cellular Properties of Near-IR [a]-Phenanthrene-fused BODIPYs. The Journal of Organic Chemistry, 2017, 82, 9744.

7.      Zhao, N.; Williams, M. T.; Zhou, Z.; Fronczek, F. R.; Sibrian-Vazquez, M.; Jois, D. S.; Vicente, M.G.H. Synthesis, and Evaluation of EGFR-targeted BODIPY-Peptide Conjugates. Bioconjugate Chemistry, 2017,28, 1566.

8.      Zhao, N.; Xuan, S.; Franczek, F. R.; Smith, K. M.; Vicente, M. G. H. Enhanced Hypsochromic Shifts, Quantum Yield, and pi-pi Interactions, in a meso,β-Heteroaryl-fused BODIPY, The Journal of Organic Chemistry, 2017, 82, 3880.

9.      Zhao, N.; Fabre, B.; Bobadova-Parvanova, P.; Franczek, F. R.; Vicente, M.G.H. Synthesis and Electropolymerization of a series of 2,2’-(ortho-Carboranyl)bisthiophenes. Journal of Organometallic Chemistry, 2017, 828, 157.

10.   Xuan, S.^†; Zhao, N.^†; Ke, X.; Zhou, Z.; Franczek, F. R.; Kadish, K. M.; Smith, K. M.; Vicente, M.G.H. Synthesis and Optophysical Investigation of a Series of Push-Pull Boron Dipyrromethenes (BODIPYs). The Journal of Organic Chemistry, 2017. 82, 2545.(^†co-first author)

11.   Zhao, N.; Xuan, S.; Fronczek, F. R.; Smith, K. M.; Byrd, B.; Vicente, M.G.H. Synthesis and Regioselective Functionalization of Perhalogenated BODIPYs. Organic & Biomolecular Chemistry, 2016, 14, 6184. Featuredas 2016 “Hot article”

12.   Zhao, N.; Xuan, S.; Fronczek, F. R.; Smith, K. M.; Vicente, M. G. H.  Stepwise Polychlorination of 8-Chloro-BODIPY and Regioselective Functionalization of 2,3,5,6,8-Pentachloro-BODIPY. The Journal of Organic Chemistry, 2015,80, 8377.                                                             

13.   Zhao, N.; Vicente, M.G.H.; Fronczek, F. R.; Smith, K. M.Synthesis of 3,8-Dichloro-6-ethyl-1,2,5,7-tetramethyl–BODIPY from an Asymmetric Dipyrroketone and Reactivity Studies at the 3,5,8-Positions. Chemistry - A European Journal,2015, 21, 6181.

14.   Shalini Chopra, Kai Trepka, Sasank Sakhamuri, Alberto Gonzales, Jun Zhu, Emily Egusa, Jie Zhou, Kevin Leung, Ning Zhao, Nima Hooshdaran, James Wells, Felix Feng, Jonathan Chou, and Michael Evans, Theranostic targeting of CUB domain containing protein 1 (CDCP1) in basal subtypes bladder cancer, 2023, Clinical cancer research, Accepted.

15.   Jiang, H.; Muir, K.R.; Gonciarz, L.R.; Olshen, B.A.; Yeh, I.; Hann, C.B.; Zhao, N.; Wang, Y-H.; Behr, C. S.; Korkola, E.J.; Evans, J.M. Collisson, A.E.; Renslo R.A. Exploiting KRAS-driven Ferroaddiction in Cancer Through Ferrous Iron-Activatable Drug Conjugates (FeADC). Journal of Experimental Medicine, 2022, 219, 4.

16.   Kim, H.; Huang, Y.; Zhao, N.; Wang, Y.; Sakhamuri, S.; Chopra, S.; Hooshdaran, N.; Sriram, R.; Aggarwal, R.T.; Aggarwal, R.; Evans J. M. In Vivo Profiling with 18F-YJH08 Reveals Diverse Tissue Patterns of Antagonist/Glucocorticoid Receptor Interactions. Molecular Pharmaceutics 2022, 19, 704.

17.   Huang, Y.; Zhao, N.; Wang, Y.; Truillet, C.; Wei, J.; Parker F.L.M.; Blecha, E.; Drake, R.C.; VanBrocklin, F. H.; Ruiz, G. D.; Jacobson, P.M.; Aggarwal, R.; Behr, C.S.; Flavell, R.R.; Wilson, M. D.; Villanueva-Meyer, E. J.; Seo, Y.; Evans J. M. The synthesis and structural requirements for measuring glucocorticoid receptor expression in vivo with (±)-11C-YJH08 PET. Journal of Nuclear medicine, 2021, 62, 723.

18.   Huang, Y.; Zhao, N.; Wang, Y.; Truillet, C.; Wei, J.; Blecha, E.; VanBrocklin, F. H.; Seo, Y.; Sriram, R.; Kurhanewicz, J.; Aggarwal, R.; Behr, C.S.; Wilson, M. D.; Villanueva-Meyer, E. J.; Evans J. M. [18F]-YJH08, a PET radioligand for multidimensional analysis of glucocorticoid receptor expression in vivo. ACS Chemical Biology, 2020, 15, 1381.

19.   Wang, S.; Li, J.; Hua, J.; Su, Y.; Vera, D.; Zhao, W.; Jayaraman, W.; Huynh, T.; Zhao, N.; Wang, Y-H.; Huang, Y.; Qin, F.; Shen, S.; Gioeli, D.; Dreicer, R.; Sriram, R.; Egusa, E.; Chou, J.; Feng, F.; Aggarwal, R.; Evans, M.; Seo, Y.; Liu, B.; Flavell, R.; He, J. Molecular imaging of prostate cancer targeting CD46 using immunoPET, Clinical Cancer Research,2020,27, 1305.

20.   Moroz, A.; Wang, Y.; Sharib, J.; Wei, J.; Zhao, N.; Huang, Y.; Chen, Z.; Martinko, A.; Zhou, J.; Lim, S.; Zhang, L.; Seo, Y.; Carlin, S.; Leung, K.; Collisson, E.; Kirkwood, K.; Wells, J.; Evans, M. Theranostic Targeting of CUB Domain Containing Protein 1 in Pancreatic Cancer. Clinical Cancer Research, 2020, 26, 3608.A

21.   Zhang, G.; Zhao, N.; Bobadova-Parvanova, P.; Wang, M.; Franczek, F. R.; Smith, K. M.; Vicente, M.G.H. Synthesis, Spectroscopic Properties, and Computational Study of E/Z-ethenyl and ethynyl-linked BODIPYs. The Journal of Physical Chemistry A, 2018, 122, 6256.

22.   Xuan, S.; Zhao, N.; Zhou, Z.; Franczek, F. R.; Vicente, M.G.H. Synthesis and In Vitro Studies of a Series of Carborane-containing Boron Dipyrromethenes (BODIPYs). Journal of Medicinal Chemistry.2016, 59, 2109.